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HTS Gene expression / SNP analysis
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Early prediction of drug induced organ-specific toxicity. Toxicogenomics analysis of tissue- and organ-specific gene markers on nanocapillary HTS QRT-PCR panels. Expression of 56 genes are followed after in vivo administration of drugs in mouse liver heart, brain and kidney.
Avidin uses the high - throughput nanocapillary real-time PCR technology for SNP analysis (Applied Biosystems) and for gene expression analysis (BioTrove) for in-house developments and for service. The technology merges the high-throughput of DNA microarrays with the sound characteristics of QRT-PCR, therefore ideal for genomics screenings. The nanotiter plate consists of 3072 through-holes grouped in 48 subarrays of 64 through-holes. Each through-hole consists of an independent 33 nL PCR assay, thus enabling a large number of PCR to be made simultaneously on hundreds of samples.|
Cancer
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Researchers at Avidin have synthesized analogues of novel Immune Modulatory Drugs (IMIDs) which may have benefits over the current treatments for multiple myeloma (MM), leukemias and other cancers.
In this project Avinomid develops lipid-based drugs for glioma. Lipid-based anti-cancer drugs are neither in the process of development nor in the market at present.
Avidin has discovered in collaboration with others cytoprotective compounds with a novel chemical structure scaffold. After chemical optimization and SAR analysis Q-50 was selected as the lead-compound for cardiovascular and neuroprotective indications.| Avidin at Asia Roadshow |
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AVIDIN is participating in an ASIA biotech roadshow passing through Hongkong, Singapore and Japan, where the biggest Asian biotech show, BioJapan is held at that time (Oct. 7-9, 2009). Aim of the roadshow is to map business opportunities of the Fare East and to establish new contacts for campaigning Avidin. |
| Succesful beta-test for BioTrove |
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Avidin has successfully finished in June, 2009 a beta-test validation study with BioTrove for pre-designed and validated TaqMan probes from Applied Biosystems, which can be applied to OpenArrayTM plates resulting superior reproducibility and low STDEV values for Ct values.
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